A Review Of indazole carboxamide
Substitution at R3 having a halogen or alkoxy group (74f–74i) brought about a slight rise in cellular potency Together with the halide analogs (74g–h) exhibiting maximum the potency while in the group. Even further optimization brought about the discovery of 74i–j, with 74k as essentially the most active compound during the sequence (pIC50 =